Inhibition of CIP2A determines erlotinib-induced apoptosis in hepatocellular carcinoma.

Abstract

Erlotinib is a small-molecular inhibitor of epidermal growth factor receptor (EGFR). Here, we identify that cancerous inhibitor of protein phosphatase 2A (CIP2A) is a major determinant mediating erlotinib-induced apoptosis in hepatocellular carcinoma (HCC). Erlotinib showed differential effects on apoptosis in 4 human HCC cell lines. Erlotinib induced… (More)
DOI: 10.1016/j.bcp.2012.11.009

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