Inhibition of CDK5 Alleviates the Cardiac Phenotypes in Timothy Syndrome

  title={Inhibition of CDK5 Alleviates the Cardiac Phenotypes in Timothy Syndrome},
  author={Loujin Song and Seon-hye E. Park and Yehuda Isseroff and K. Morikawa and M. Yazawa},
  journal={Stem Cell Reports},
  pages={50 - 57}
Summary L-type calcium channel CaV1.2 plays an essential role in cardiac function. The gain-of-function mutations in CaV1.2 have been reported to be associated with Timothy syndrome, a disease characterized by QT prolongation and syndactyly. Previously we demonstrated that roscovitine, a cyclin-dependent kinase (CDK) inhibitor, could rescue the phenotypes in induced pluripotent stem cell-derived cardiomyocytes from Timothy syndrome patients. However, exactly how roscovitine rescued the… Expand
10 Citations
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