Inhibition of CCN6 (Wnt-1-induced signaling protein 3) down-regulates E-cadherin in the breast epithelium through induction of snail and ZEB1.

@article{Huang2008InhibitionOC,
  title={Inhibition of CCN6 (Wnt-1-induced signaling protein 3) down-regulates E-cadherin in the breast epithelium through induction of snail and ZEB1.},
  author={Wei Huang and Yanhong Zhang and Sooryanarayana Varambally and Arul M. Chinnaiyan and Mousumi Banerjee and Sof{\'i}a D. Merajver and Celina G Kleer},
  journal={The American journal of pathology},
  year={2008},
  volume={172 4},
  pages={893-904}
}
The cysteine-rich protein CCN6 [or Wnt-1-induced signaling protein 3 (WISP3)] exerts tumor-suppressive effects in aggressive inflammatory breast cancer. Loss of CCN6 is associated with poorly differentiated phenotypes and increased invasion. Here, we show that reduction of CCN6 expression occurs in 60% of invasive breast carcinomas and is associated with axillary lymph node metastases. Furthermore, low CCN6 expression in invasive carcinoma tissue samples correlates with reduced expression of E… CONTINUE READING