Inhibition of C6 glioma cell proliferation by anandamide, 1-arachidonoylglycerol, and by a water soluble phosphate ester of anandamide: variability in response and involvement of arachidonic acid.

@article{Fowler2003InhibitionOC,
  title={Inhibition of C6 glioma cell proliferation by anandamide, 1-arachidonoylglycerol, and by a water soluble phosphate ester of anandamide: variability in response and involvement of arachidonic acid.},
  author={Christopher J Fowler and K O Jonsson and Anna Erika Elisabeth Andersson and Juha Juntunen and Tomi J{\"a}rvinen and S{\'e}verine Vandevoorde and Didier Lambert and Jeffrey C. Jerman and Darren Smart},
  journal={Biochemical pharmacology},
  year={2003},
  volume={66 5},
  pages={757-67}
}
It has previously been shown that the endocannabinoids anandamide and 2-arachidonoylglycerol (2-AG) inhibit the proliferation of C6 glioma cells in a manner that can be prevented by a combination of capsazepine (Caps) and cannabinoid (CB) receptor antagonists. It is not clear whether the effect of 2-AG is due to the compound itself, due to the rearrangement to form 1-arachidonoylglycerol (1-AG) or due to a metabolite. Here, it was found that the effects of 2-AG can be mimicked with 1-AG, both… CONTINUE READING

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