Inhibition of Breast Cancer Cell Growth In vitro and In vivo: Effect of Restoration of Wwox Expression

  title={Inhibition of Breast Cancer Cell Growth In vitro and In vivo: Effect of Restoration of Wwox Expression},
  author={D. Iliopoulos and M. Fabbri and T. Druck and H. Qin and S. Han and K. H{\"u}bner},
  journal={Clinical Cancer Research},
  pages={268 - 274}
  • D. Iliopoulos, M. Fabbri, +3 authors K. Hübner
  • Published 2007
  • Biology, Medicine
  • Clinical Cancer Research
  • Purpose: The WWOX gene is down-regulated in breast cancer and loss of Wwox expression correlates with important clinical features of breast cancer. Thus, we have examined the effect of restoration of Wwox expression in breast cancer-derived cells. Experimental Design: Wwox protein expression was restored by the following: (a) infection with a recombinant adenovirus carrying WWOX cDNA (Ad-WWOX) or (b) treatment with the DNA methyltransferase inhibitor, 5-aza-2′-deoxycytidine, to activate the… CONTINUE READING
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