Inhibition of Breast Cancer Cell Growth In vitro and In vivo: Effect of Restoration of Wwox Expression

@article{Iliopoulos2007InhibitionOB,
  title={Inhibition of Breast Cancer Cell Growth In vitro and In vivo: Effect of Restoration of Wwox Expression},
  author={D. Iliopoulos and M. Fabbri and T. Druck and H. Qin and S. Han and K. H{\"u}bner},
  journal={Clinical Cancer Research},
  year={2007},
  volume={13},
  pages={268 - 274}
}
  • D. Iliopoulos, M. Fabbri, +3 authors K. Hübner
  • Published 2007
  • Biology, Medicine
  • Clinical Cancer Research
  • Purpose: The WWOX gene is down-regulated in breast cancer and loss of Wwox expression correlates with important clinical features of breast cancer. Thus, we have examined the effect of restoration of Wwox expression in breast cancer-derived cells. Experimental Design: Wwox protein expression was restored by the following: (a) infection with a recombinant adenovirus carrying WWOX cDNA (Ad-WWOX) or (b) treatment with the DNA methyltransferase inhibitor, 5-aza-2′-deoxycytidine, to activate the… CONTINUE READING
    83 Citations

    Figures and Topics from this paper.

    Ectopic WWOX Expression Inhibits Growth of 5637 Bladder Cancer Cell In Vitro and In Vivo
    • 11
    Functional and Clinical Characterization of the Putative Tumor Suppressor WWOX in Non-small Cell Lung Cancer
    • S. Becker, B. Markova, +6 authors M. Schuler
    • Biology, Medicine
    • Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
    • 2011
    • 13
    • PDF
    Wwox inactivation enhances mammary tumorigenesis
    • 51
    • PDF
    Decreased WWOX expression promotes angiogenesis in osteosarcoma.
    • 9
    • PDF
    The role of the WWOX gene in leukemia and its mechanisms of action.
    • 20
    • PDF
    Diverse effect of WWOX overexpression in HT29 and SW480 colon cancer cell lines
    • 14
    • Highly Influenced
    • PDF
    Wwox–Brca1 interaction: role in DNA repair pathway choice
    • 24
    • PDF
    Wwox suppresses breast cancer cell growth through modulation of the hedgehog-GLI1 signaling pathway.
    • 9
    Characterization of WWOX expression and function in canine mast cell tumors and malignant mast cell lines
    Regulation of cell signaling and apoptosis by tumor suppressor WWOX
    • 18

    References

    SHOWING 1-10 OF 47 REFERENCES
    WWOX gene restoration prevents lung cancer growth in vitro and in vivo
    • 135
    • PDF
    A role for the WWOX gene in prostate cancer.
    • 102
    • PDF
    The Tumor Suppressor Gene WWOX at FRA16D Is Involved in Pancreatic Carcinogenesis
    • 125
    • PDF
    Adenovirus-mediated p53 gene therapy inhibits human sarcoma tumorigenicity
    • 29
    • PDF
    Induction of apoptosis in p16INK4A mutant cell lines by adenovirus-mediated overexpression of p16INK4A protein
    • 31
    • PDF
    Frequent loss of WWOX expression in breast cancer: correlation with estrogen receptor status
    • 93