Inhibition of BmNPV replication in Bombyx mori cell by dsRNA triggered RNA interference

@article{Ying2004InhibitionOB,
  title={Inhibition of BmNPV replication in Bombyx mori cell by dsRNA triggered RNA interference},
  author={X. Ying and Zhu Cheng-gang and Jin Yongfeng and Zhang Yao-zhou},
  journal={Chinese Science Bulletin = Kexue Tongbao},
  year={2004},
  volume={49},
  pages={1261 - 1266}
}
  • X. Ying, Zhu Cheng-gang, +1 author Zhang Yao-zhou
  • Published 2004
  • Biology, Medicine
  • Chinese Science Bulletin = Kexue Tongbao
  • RNA interference (RNAi) causes degradation of targeted endogenous RNA in many diverse organisms. To investigate the effect of dsRNA on silkworm cells, we transfected three kinds of synthetic dsRNAs of 435 bp(Ap1), 300 bp(Ap2) and 399 bp(AH) in length against the various regions of BmNPV’s DNA polymerase gene and DNA helicase gene, which are indispensable for viral replication in silkworm cells by TransMessengerTM transfection Reagent. Results indicated that in the experiment where silkworm… CONTINUE READING

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    RNA interference is mediated by 21- and 22-nucleotide RNAs.
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