Inhibition of Benzo(a)pyrene Metabolism Catalyzed by Mouse and Hamster Lung Microsomes


Induced and constitutive microsomal enzymes of mouse and hamster lungs catalyze both the hydroxylation of benzo(a)pyrene and reactions that lead to its irreversible binding to macromolecules. For mouse and hamster, the induced lung hydroxylases have K m values of 1.10 and 0.52 ~M, respectively. The induced hydroxylases are strongly inhibited by 7,8… (More)


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