Inhibition of Bcl-xL by ABT-737 enhances chemotherapy sensitivity in neurofibromatosis type 1-associated malignant peripheral nerve sheath tumor cells.

@article{Lee2012InhibitionOB,
  title={Inhibition of Bcl-xL by ABT-737 enhances chemotherapy sensitivity in neurofibromatosis type 1-associated malignant peripheral nerve sheath tumor cells.},
  author={Su-Jin Lee and Ho-jin Park and Young-Hwa Kim and Bo-Young Kim and Hyun-Seok Jin and H Jeffrey Kim and Jae-Ho Han and Hyunee Yim and Seon-Yong Jeong},
  journal={International journal of molecular medicine},
  year={2012},
  volume={30 2},
  pages={443-50}
}
Neurofibromatosis type 1 (NF1) is one of the most commonly inherited autosomal dominant disorders. The malignant peripheral nerve sheath tumor (MPNST) is a major cause of mortality in patients with NF1. In this study, we found that overexpression of Bcl-xL in the established NF1-associated MPNST cell line and primary tissue cultured MPNST cells derived from an NF1 patient was closely associated with anticancer drug resistance of the… CONTINUE READING