Inhibition of Bacterial Conjugation by Phage M13 and Its Protein g3p: Quantitative Analysis and Model

@inproceedings{Lin2011InhibitionOB,
  title={Inhibition of Bacterial Conjugation by Phage M13 and Its Protein g3p: Quantitative Analysis and Model},
  author={Abraham Lin and Jos{\'e} Jim{\'e}nez and Julien Derr and Pedro E. Vera and Michael L. Manapat and Kevin M Esvelt and Laura Villanueva and David R Liu and Irene A. Chen},
  booktitle={PloS one},
  year={2011}
}
Conjugation is the main mode of horizontal gene transfer that spreads antibiotic resistance among bacteria. Strategies for inhibiting conjugation may be useful for preserving the effectiveness of antibiotics and preventing the emergence of bacterial strains with multiple resistances. Filamentous bacteriophages were first observed to inhibit conjugation several decades ago. Here we investigate the mechanism of inhibition and find that the primary effect on conjugation is occlusion of the… CONTINUE READING
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