Inhibition of Bacterial Carbonic Anhydrases as a Novel Approach to Escape Drug Resistance.

Abstract

BACKGROUND Clinically used antibiotics act through one of these four mechanisms: cell wall biosynthesis inhibition, inhibition of protein biosynthesis, interference with DNA and RNA synthesis and the folate pathway. OBJECTIVE The metalloenzymes carbonic anhydrases (CAs, EC 4.2.1.1) widespread in microorganisms and present as three genetically distinct… (More)
DOI: 10.2174/1568026617666170104101058

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