Inhibition of BMP signaling overcomes acquired resistance to cetuximab in oral squamous cell carcinomas.

Abstract

Despite expressing high levels of the epidermal growth factor receptor (EGFR), a majority of oral squamous cell carcinoma (OSCC) patients show limited response to cetuximab and ultimately develop drug resistance. However, mechanism underlying cetuximab resistance in OSCC is not clearly understood. Here, using a mouse orthotopic xenograft model of OSCC, we… (More)
DOI: 10.1016/j.canlet.2017.11.013

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