Inhibition of Aurora-A kinase induces cell cycle arrest in epithelial ovarian cancer stem cells by affecting NFĸB pathway.

@article{Chefetz2011InhibitionOA,
  title={Inhibition of Aurora-A kinase induces cell cycle arrest in epithelial ovarian cancer stem cells by affecting NFĸB pathway.},
  author={Ilana Chefetz and Jennie C. Holmberg and Ayesha B. Alvero and Irene P Visintin and Gil Mor},
  journal={Cell cycle},
  year={2011},
  volume={10 13},
  pages={2206-14}
}
Recurrent ovarian cancer is resistant to conventional chemotherapy. A sub-population of ovarian cancer cells, the epithelial ovarian cancer stem cells (EOC stem cells) have stemness properties, constitutive NFκB activity, and represent the chemoresistant population. Currently, there is no effective treatment that targets these cells. Aurora-A kinase (Aurora-A) is associated with tumor initiation and progression and is overexpressed in numerous malignancies. The aim of this study is to determine… CONTINUE READING

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