Inhibition of Apoptosis after Thymineless Stress Is Conferred by Oncogenic KRas in Colon Carcinoma Cells 1

  • Janet, A..., +6 authors Tiliman
  • Published 2005
Ras functions as a molecular switch for several downstream targets and may promote either apoptosis or survival dependent upon the cell system and stimulus. The functional significance of a transfected K-Ras oncogene in influencing apoptosis induced by thymineless stress was examined in a thymidylate synthase (TS)-deficient (TS) colon carcinoma cell line… CONTINUE READING