Inhibition of Allergic Inflammation by C-Terminal Peptides of the Prohormone Submandibular Rat 1 (SMR-1)

  title={Inhibition of Allergic Inflammation by C-Terminal Peptides of the Prohormone Submandibular Rat 1 (SMR-1)},
  author={R. D{\'e}ry and R. Mathison and J. Davison and A. Befus},
  journal={International Archives of Allergy and Immunology},
  pages={201 - 204}
  • R. Déry, R. Mathison, +1 author A. Befus
  • Published 2001
  • Medicine
  • International Archives of Allergy and Immunology
  • Background: The C-terminal of the prohormone submandibular rat 1 protein (SMR-1) contains several small peptides that reduce the severity of allergic inflammation and septic shock, and are part of the cervical sympathetic trunk-submandibular gland (SMG) axis of neuroendocrine immunology. These peptides include the heptapeptide, submandibular gland peptide-T and the tripeptide FEG. The D-isomeric form of this tripeptide, feG, which is active when administered orally, reduces LPS-provoked… CONTINUE READING
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