Inhibition of Akt survival pathway by a small-molecule inhibitor in human glioblastoma.

@article{Koul2006InhibitionOA,
  title={Inhibition of Akt survival pathway by a small-molecule inhibitor in human glioblastoma.},
  author={Dimpy Koul and Ruijun Shen and Sherry A Bergh and Xiaoyang Sheng and Shishir Shishodia and Tiffany A Lafortune and Yiling Lu and John Frederick de Groot and Gordon B. Mills and W. K. Alfred Yung},
  journal={Molecular cancer therapeutics},
  year={2006},
  volume={5 3},
  pages={637-44}
}
Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) and Akt are important regulators of the phosphatidylinositol 3-kinase (PI3K) pathway and thus are important to the regulation of a wide spectrum of tumor-related biological processes. Akt regulates several critical cellular functions, including cell cycle progression; cell migration, invasion, and survival; and angiogenesis. Decreased expression of PTEN and overexpression of the Akt proto-oncogene, which is located downstream of… CONTINUE READING