Inhibition of Akt kinase by cell-permeable ceramide and its implications for ceramide-induced apoptosis.

@article{Zhou1998InhibitionOA,
  title={Inhibition of Akt kinase by cell-permeable ceramide and its implications for ceramide-induced apoptosis.},
  author={Honglin Zhou and Scott A. Summers and Morris J Birnbaum and Randall Pittman},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 26},
  pages={16568-75}
}
Ceramide is an important lipid messenger involved in mediating a variety of cell functions including apoptosis. However, mechanisms responsible for ceramide-induced apoptosis remain unclear. We investigated the possibility that ceramide may decrease antiapoptotic signaling in cells by inhibiting Akt kinase activity. Our data show that C2-ceramide induces apoptosis in HMN1 motor neuron cells and decreases both basal and insulin- or serum-stimulated Akt kinase activity 65-70%. These results are… CONTINUE READING
104 Extracted Citations
0 Extracted References
Similar Papers

Citing Papers

Publications influenced by this paper.
Showing 1-10 of 104 extracted citations

Similar Papers

Loading similar papers…