Corpus ID: 88099427

Inhibition of Aflatoxin $B_1$ Biosynthesis by Piperlongumine Isolated from Piper longum L.

  title={Inhibition of Aflatoxin \$B\_1\$ Biosynthesis by Piperlongumine Isolated from Piper longum L.},
  author={Sung-Eun Lee and Noreen E. Mahoney and Bruce C.V. Campbell},
  journal={Journal of Microbiology and Biotechnology},
The alkaloids, piperlongumine, piperine, pipemonaline, and piperoctadecalidine, isolated from Piper longum L., were found to inhibit the biosynthesis of aflatoxin B 1 (AFB 1 ) in Aspergillus flavus WRRC 3-90-42-12. Piperlongumine was the most active among the compounds tested, with a 96% inhibition of AFB 1 biosynthesis at 0.2% (w/v) supplement in a potato dextrose agar (PDA) medium. The three other piperidine alkaloids, piperine, pipemonaline, and piperoctadecalidine, also inhibited the… Expand

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