Inhibition of Aerobic Glycolysis Attenuates Disease Progression in Polycystic Kidney Disease.

@article{Riwanto2016InhibitionOA,
  title={Inhibition of Aerobic Glycolysis Attenuates Disease Progression in Polycystic Kidney Disease.},
  author={Meliana Riwanto and Sarika Kapoor and Daniel Arturo Leon Rodriguez and Ilka Edenhofer and Stephan Segerer and Rudolf Peter W{\"u}thrich},
  journal={PloS one},
  year={2016},
  volume={11 1},
  pages={e0146654}
}
Dysregulated signaling cascades alter energy metabolism and promote cell proliferation and cyst expansion in polycystic kidney disease (PKD). Here we tested whether metabolic reprogramming towards aerobic glycolysis ("Warburg effect") plays a pathogenic role in male heterozygous Han:SPRD rats (Cy/+), a chronic progressive model of PKD. Using microarray analysis and qPCR, we found an upregulation of genes involved in glycolysis (Hk1, Hk2, Ldha) and a downregulation of genes involved in… CONTINUE READING
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