• Corpus ID: 24935715

Inhibition of ATP-sensitive potassium channels attenuates propofol-induced vasorelaxation.

@article{Lam2010InhibitionOA,
  title={Inhibition of ATP-sensitive potassium channels attenuates propofol-induced vasorelaxation.},
  author={Chen-Fuh Lam and P J Chang and Yung-An Chen and Chin-Yi Yeh and Yu-Chuan Tsai},
  journal={Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine},
  year={2010},
  volume={12 3},
  pages={
          186-90
        }
}
  • C. Lam, P. Chang, Y. Tsai
  • Published 2010
  • Biology, Medicine
  • Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine
BACKGROUND Infusion of propofol often causes significant vasodilation, which is followed by a profound drop in blood pressure. However, the exact underlying molecular mechanisms of this clinically important phenomenon remain unclear. OBJECTIVE To determine the biological role of endothelium in propofol-induced vasorelaxation and the underlying molecular mechanisms of this response in the rat aorta. DESIGN, SETTING AND SUBJECTS Ex vivo assessment of vasomotor function in rat aortic rings… 

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