Inhibition of APP trafficking by tau protein does not increase the generation of amyloid-beta peptides.

@article{Goldsbury2006InhibitionOA,
  title={Inhibition of APP trafficking by tau protein does not increase the generation of amyloid-beta peptides.},
  author={Claire S Goldsbury and Maria-Magdalena Mocanu and Edda Thies and Christoph Kaether and Christian Haass and Patrick Keller and Jacek Biernat and Eckhard Mandelkow and E. -M. Mandelkow},
  journal={Traffic},
  year={2006},
  volume={7 7},
  pages={873-88}
}
Amyloid-beta, a peptide derived from the precursor protein APP, accumulates in the brain and contributes to the neuropathology of Alzheimer's disease. Increased generation of amyloid-beta might be caused by axonal transport inhibition, via increased dwell time of APP vesicles and thereby higher probability of APP cleavage by secretase enzymes residing on the same vesicles. We tested this hypothesis using a neuronal cell culture model of inhibited axonal transport and by imaging vesicular… CONTINUE READING
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