Inhibition of AMPK catabolic action by GSK3.

  title={Inhibition of AMPK catabolic action by GSK3.},
  author={Tsukasa Suzuki and Dave Bridges and Daisuke Nakada and Georgios Skiniotis and Sean J Morrison and Jiandie D Lin and Alan R. Saltiel and Ken Inoki},
  journal={Molecular cell},
  volume={50 3},
AMP-activated protein kinase (AMPK) regulates cellular energy homeostasis by inhibiting anabolic and activating catabolic processes. While AMPK activation has been extensively studied, mechanisms that inhibit AMPK remain elusive. Here we report that glycogen synthase kinase 3 (GSK3) inhibits AMPK function. GSK3 forms a stable complex with AMPK through interactions with the AMPK β regulatory subunit and phosphorylates the AMPK α catalytic subunit. This phosphorylation enhances the accessibility… CONTINUE READING
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Inhibition of AMPK Catabolic Action by GSK3

  • Suzuki
  • Molecular Cell (2013),
  • 2013
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