Inhibition of AKT abrogates chemotherapy-induced NF-kappaB survival mechanisms: implications for therapy in pancreatic cancer.

@article{Fahy2004InhibitionOA,
  title={Inhibition of AKT abrogates chemotherapy-induced NF-kappaB survival mechanisms: implications for therapy in pancreatic cancer.},
  author={Bridget Noel Fahy and Michael G. Schlieman and Subbulakshmi Virudachalam and Richard Bold},
  journal={Journal of the American College of Surgeons},
  year={2004},
  volume={198 4},
  pages={591-9}
}
BACKGROUND When activated, the nuclear factor (NF)-kappaB pathway is a potent cellular signal that inhibits apoptotic cell death. Pancreatic cancer is resistant to the apoptotic effect of chemotherapy, though it is unclear whether this is an inherent feature or a survival signal engaged in response to chemotherapy. We investigated whether pancreatic cancer cells activate the NF-kappaB pathway in response to chemotherapy and whether inhibition of this response altered the apoptotic efficacy of… CONTINUE READING

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