Inhibition of AIM2 inflammasome activation alleviates GSDMD-induced pyroptosis in early brain injury after subarachnoid haemorrhage

@article{Yuan2020InhibitionOA,
  title={Inhibition of AIM2 inflammasome activation alleviates GSDMD-induced pyroptosis in early brain injury after subarachnoid haemorrhage},
  author={Bin Yuan and Xiao-ming Zhou and Z. You and Wei-dong Xu and Jie-mei Fan and Shu-juan Chen and Yan-ling Han and Qi Wu and X. Zhang},
  journal={Cell Death \& Disease},
  year={2020},
  volume={11}
}
Only a few types of inflammasomes have been described in central nervous system cells. Among these, the absent in melanoma 2 (AIM2) inflammasome is primarily found in neurons, is highly specific and can be activated only by double-stranded DNA. Although it has been demonstrated that the AIM2 inflammasome is activated by poly(deoxyadenylic-deoxythymidylic) acid sodium salt and leads to pyroptotic neuronal cell death, the role of AIM2 inflammasome-mediated pyroptosis in early brain injury (EBI… Expand
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