Inhibition of ADH release in the rat by narcotic antagonists.

  title={Inhibition of ADH release in the rat by narcotic antagonists.},
  author={M. Miller},
  volume={19 3},
  • M. Miller
  • Published 1975
  • Biology, Medicine
  • Neuroendocrinology
  • The diuretic action of two new narcotic antagonists, oxilorphan and butorphanol, was studied in rats heterozygous for hereditary hypothalmic diabetes insipidus. Both drugs caused a prompt increase in urine volume and a decrease in urine osmolality with an associated decrease in urinary ADH excretion. The effects appeared to be dose related and of short duration. Tolerance to butorphanol administration was evident on repeated daily injections. The diuretic effect was not associated with… CONTINUE READING
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