Inhibition of ABCA1 Protein Expression and Cholesterol Efflux by TNF α in MLO-Y4 Osteocytes

@article{Wehmeier2015InhibitionOA,
  title={Inhibition of ABCA1 Protein Expression and Cholesterol Efflux by TNF α in MLO-Y4 Osteocytes},
  author={Kent R. Wehmeier and William Kurban and Chandrikha Chandrasekharan and Luisa M. Onstead-Haas and Arshag D Mooradian and Michael J. Haas},
  journal={Calcified Tissue International},
  year={2015},
  volume={98},
  pages={586-595}
}
Hip fracture and myocardial infarction cause significant morbidity and mortality. In vivo studies raising serum cholesterol levels as well as pro-inflammatory cytokines such as TNF α manifest bone loss and atherosclerotic vascular disease, suggesting that abnormalities of cholesterol transport may contribute to osteoporosis. We used the mouse osteocyte cell line (MLO-Y4) to investigate the effects of TNF α on the expression of cholesterol acceptor proteins such as apolipoprotein A-I (apo A-I… CONTINUE READING
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