Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain

  title={Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain},
  author={Walter A Kostich and Brian Hamman and Yu-Wen Li and Sreenivasulu Naidu and Kumaran Dandapani and Jianlin Feng and Amy H. Easton and Clotilde Bourin and Kevin Baker and Jason B. Allen and Katerina V. Savelieva and Justin V. Louis and Manoj Kumar Dokania and Saravanan Elavazhagan and Pradeep Vattikundala and Vivek Sharma and Manish Lal Das and Ganesh M. Shankar and Anoop 4 Kumar and Vinay K. Holenarsipur and Michael Gulianello and Ted Molski and Jeffrey M. Brown and Martin Lewis and Yanling Huang and Yifeng Lu and Rick L Pieschl and Kevin O’Malley and Jonathan S Lippy and Amr Nouraldeen and Thomas H. Lanthorn and Guilan Ye and A. D. Wilson and Anand Balakrishnan and Rex Denton and James E Grace and Kimberley A. Lentz and Kenneth S. Santone and Yingzhi Bi and Alan J Main and Jon Swaffield and Ken Carson and Sandhya Mandlekar and Reeba Kannimel Vikramadithyan and Susheel J. Nara and Carolyn D Dzierba and Joanne Bronson and John E. Macor and Robert C. Zaczek and Ryan S. Westphal and Laszlo Kiss and Linda Bristow and Charles M. Conway and Brian P. Zambrowicz and Charles F. Albright},
  booktitle={The Journal of pharmacology and experimental therapeutics},
To identify novel targets for neuropathic pain, 3097 mouse knockout lines were tested in acute and persistent pain behavior assays. One of the lines from this screen, which contained a null allele of the adapter protein-2 associated kinase 1 (AAK1) gene, had a normal response in acute pain assays (hot plate, phase I formalin), but a markedly reduced response to persistent pain in phase II formalin. AAK1 knockout mice also failed to develop tactile allodynia following the Chung procedure of… CONTINUE READING
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