Inhibition of 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis by retinyl acetate.

Abstract

The administration of 2.5 mg retinyl acetate daily in the diet to female Sprague-Dawley rats beginning 7 days after the intragastric instillation of either 2.5, 5, or 15 mg 7,12-dimethylbenz(a)anthracene (CMBA) resulted in a reduction in the incidence of benign mammary tumors of 37, 30, and 31%, respectively. An equally significant reduction in the number… (More)

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@article{Moon1976InhibitionO7, title={Inhibition of 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis by retinyl acetate.}, author={Richard C. Moon and Clinton J. Grubbs and Michael B. Sporn}, journal={Cancer research}, year={1976}, volume={36 7 PT 2}, pages={2626-30} }