Inhibition of 5alpha-reduced steroid biosynthesis impedes acquisition of ethanol drinking in male C57BL/6J mice.

@article{Ford2008InhibitionO5,
  title={Inhibition of 5alpha-reduced steroid biosynthesis impedes acquisition of ethanol drinking in male C57BL/6J mice.},
  author={M. Ford and N. Yoneyama and M. N. Strong and Andrea M. Fretwell and M. Tanchuck and D. Finn},
  journal={Alcoholism, clinical and experimental research},
  year={2008},
  volume={32 8},
  pages={
          1408-16
        }
}
  • M. Ford, N. Yoneyama, +3 authors D. Finn
  • Published 2008
  • Medicine
  • Alcoholism, clinical and experimental research
  • BACKGROUND Allopregnanolone (ALLO) is a physiologically relevant neurosteroid modulator of GABA(A) receptors, and it exhibits a psychopharmacological profile that closely resembles the post-ingestive effects of ethanol. The 5alpha-reductase inhibitor finasteride (FIN), which inhibits biosynthesis of ALLO and structurally related neurosteroids, was previously demonstrated to reduce the maintenance of limited-access ethanol consumption. The primary aim of the current work was to determine whether… CONTINUE READING
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