Inhibition of 5-lipoxygenase induces cell growth arrest and apoptosis in rat Kupffer cells: implications for liver fibrosis.

@article{Titos2003InhibitionO5,
  title={Inhibition of 5-lipoxygenase induces cell growth arrest and apoptosis in rat Kupffer cells: implications for liver fibrosis.},
  author={Esther Titos and Joan Cl{\`a}ria and Anna Planagum{\`a} and Marta L{\'o}pez-Parra and Neus Villamor and Marcelina P{\'a}rrizas and Anna Carri{\'o} and Rosa Miquel and Wladimiro Jim{\'e}nez and Vicente Arroyo and Francisca Rivera and Joan Rod{\'e}s},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2003},
  volume={17 12},
  pages={1745-7}
}
The existence of an increased number of Kupffer cells is recognized as critical in the initiation of the inflammatory cascade leading to liver fibrosis. Because 5-lipoxygenase (5-LO) is a key regulator of cell growth and survival, in the current investigation we assessed whether inhibition of the 5-LO pathway would reduce the excessive number of Kupffer cells and attenuate inflammation and fibrosis in experimental liver disease. Kupffer cells were the only liver cell type endowed with a… CONTINUE READING

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FASEB journal : official publication of the Federation of American Societies for Experimental Biology • 2013
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