Inhibition of 5-lipoxygenase by MK886 augments the antitumor activity of celecoxib in human colon cancer cells.

@article{Cianchi2006InhibitionO5,
  title={Inhibition of 5-lipoxygenase by MK886 augments the antitumor activity of celecoxib in human colon cancer cells.},
  author={F. Cianchi and Camillo Cortesini and Lucia Magnelli and Elena Fanti and Laura Papucci and Nicola Schiavone and Luca Messerini and Alfredo Vannacci and Sergio Capaccioli and Federico Perna and Matteo Lulli and Valentina Fabbroni and Giuliano Perigli and Paolo Bechi and Emanuela Masini},
  journal={Molecular cancer therapeutics},
  year={2006},
  volume={5 11},
  pages={2716-26}
}
Cyclooxygenase (COX)-2 and 5-lipoxygenase (5-LOX) are key enzymes involved in arachidonic acid metabolism. Their products, prostaglandins and leukotrienes, are involved in colorectal tumor development. We aimed at evaluating whether combined blocking of the COX-2 and 5-LOX pathways might have additive antitumor effects in colorectal cancer. The expression/activity of COX-2 and 5-LOX were assessed in 24 human colorectal cancer specimens. The effects of the COX-2 inhibitor celecoxib and the 5-LOX… CONTINUE READING