Inhibition of 5'DI and 5'DII L-tiroxine (T4) monodeiodinases. Effect on the hypothalamo-pituitary ovarian axis in adult hypothyroid rats treated with T4.

@article{Ortega1996InhibitionO5,
  title={Inhibition of 5'DI and 5'DII L-tiroxine (T4) monodeiodinases. Effect on the hypothalamo-pituitary ovarian axis in adult hypothyroid rats treated with T4.},
  author={Eduardo Ortega and Alvaro Osorio and Elaine Ruiz},
  journal={Biochemistry and molecular biology international},
  year={1996},
  volume={39 4},
  pages={853-60}
}
Hypothyroid female rats were treated with T4 and their 5'DI and 5'DII deiodinases were inhibited by PTU and IOP administration to determine whether the effect of T3 on reproductive function is a primary event at hypothalamo-pituitary levels or ovarian levels. Hypothyroid adult female rats were divided into four groups: Hypothyroid without treatment (H); hypothyroid treated with T4 (H-T4); hypothyroid treated with T4 plus propylthiouracil (H-T4-PTU), and hypothyroid treated with T4 plus iopanoic… CONTINUE READING