Inhibition of 4-nitroquinoline-1-oxide-induced rat tongue carcinogenesis by the naturally occurring plant phenolics caffeic, ellagic, chlorogenic and ferulic acids.

@article{Tanaka1993InhibitionO4,
  title={Inhibition of 4-nitroquinoline-1-oxide-induced rat tongue carcinogenesis by the naturally occurring plant phenolics caffeic, ellagic, chlorogenic and ferulic acids.},
  author={Toshiyuki Tanaka and Takahiro Kojima and Toshihiko Kawamori and Aijin Wang and Masumi Suzui and Kohji Okamoto and Hideki Mori},
  journal={Carcinogenesis},
  year={1993},
  volume={14 7},
  pages={1321-5}
}
The modifying effects of dietary administration of the plant phenolic antioxidants caffeic acid (CA), ellagic acid (EA), chlorogenic acid (CGA) and ferulic acid (FA) during the initiation phase on 4-nitroquinoline-1-oxide (4-NQO)-induced tongue carcinogenesis and on the number and area of silver-stained nucleolar organizer region proteins (AgNORs), a new cell proliferation marker, of the tongue squamous epithelium were investigated in male F344 rats. Rats were fed the diet containing 500 p.p.m… CONTINUE READING
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