Inhibition of 3H-Thymidine Incorporation into Rat Liver Nuclei by E. coli L-Asparaginase

@article{Seeber1970InhibitionO3,
  title={Inhibition of 3H-Thymidine Incorporation into Rat Liver Nuclei by E. coli L-Asparaginase},
  author={Siegfried Seeber and Ulrich Weser},
  journal={Nature},
  year={1970},
  volume={225},
  pages={652-653}
}
THERE have been numerous reports dealing with the anti-tumour activity of Escherichia coli L-asparaginase in the therapy of human leukaemia. It has been postulated that the agent is without toxic action on normal tissues and that it is specific for asparagine dependent tumour cells, but neither of these assumptions has been proved1,2. When L-asparaginase… CONTINUE READING