Inhibition of 2-AG hydrolysis differentially regulates blood brain barrier permeability after injury

@inproceedings{Piro2018InhibitionO2,
  title={Inhibition of 2-AG hydrolysis differentially regulates blood brain barrier permeability after injury},
  author={Justin R. Piro and Georgette L Suidan and Jie Rong Quan and YeQing Pi and Sharon M. O’Neill and Marissa C. Ilardi and Nikolay Pozdnyakov and Thomas A Lanz and Hualin Simon Xi and Robert D. Bell and Tarek A. Samad},
  booktitle={Journal of Neuroinflammation},
  year={2018}
}
BackgroundAcute neurological insults caused by infection, systemic inflammation, ischemia, or traumatic injury are often associated with breakdown of the blood-brain barrier (BBB) followed by infiltration of peripheral immune cells, cytotoxic proteins, and water. BBB breakdown and extravasation of these peripheral components into the brain parenchyma result in inflammation, oxidative stress, edema, excitotoxicity, and neurodegeneration. These downstream consequences of BBB dysfunction can drive… CONTINUE READING
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