Inhibition of 11beta-hydroxysteroid dehydrogenase by bile acids in rats with cirrhosis.

@article{Ackermann1999InhibitionO1,
  title={Inhibition of 11beta-hydroxysteroid dehydrogenase by bile acids in rats with cirrhosis.},
  author={Daniel Ackermann and Bruno Vogt and Genevi{\`e}ve Escher and Bernhard Dick and Juerg Reichen and Brigitte M. Frey and Felix J. Frey},
  journal={Hepatology},
  year={1999},
  volume={30 3},
  pages={623-9}
}
Renal sodium retention and potassium loss occur early, in many instances in the preascitic state of cirrhosis, an observation that cannot be fully explained by increased aldosterone concentrations. We therefore hypothesize that 11beta-hydroxysteroid dehydrogenase 2 (11beta-HSD2), which protects mineralocorticoid receptors (MR) from glucocorticosteroids, is down-regulated in cirrhosis. Cirrhosis was induced by bile duct ligation in rats. The urinary ratio of (tetrahydrocorticosterone + 5alpha… CONTINUE READING
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