Inhibition of β-catenin signaling respecifies anterior-like endothelium into beating human cardiomyocytes

@inproceedings{Palpant2015InhibitionO,
  title={Inhibition of β-catenin signaling respecifies anterior-like endothelium into beating human cardiomyocytes},
  author={Nathan J. Palpant and Lil M. Pabon and Meredith Roberts and Brandon K. Hadland and Daniel Jones and Christina Jones and Randall T. Moon and Walter L. Ruzzo and Irwin D Bernstein and Ying Zheng and Charles E Murry},
  booktitle={Development},
  year={2015}
}
During vertebrate development, mesodermal fate choices are regulated by interactions between morphogens such as activin/nodal, BMPs and Wnt/β-catenin that define anterior-posterior patterning and specify downstream derivatives including cardiomyocyte, endothelial and hematopoietic cells. We used human embryonic stem cells to explore how these pathways control mesodermal fate choices in vitro. Varying doses of activin A and BMP4 to mimic cytokine gradient polarization in the anterior-posterior… CONTINUE READING
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