Inhibition of β-Cell Sodium-Calcium Exchange Enhances Glucose-Dependent Elevations in Cytoplasmic Calcium and Insulin Secretion

Abstract

OBJECTIVE The sodium-calcium exchanger isoform 1 (NCX1) regulates cytoplasmic calcium (Ca(2+)(c)) required for insulin secretion in beta-cells. NCX1 is alternatively spliced, resulting in the expression of splice variants in different tissues such as NCX1.3 and -1.7 in beta-cells. As pharmacological inhibitors of NCX1 splice variants are in development, the… (More)
DOI: 10.2337/db09-0630

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Cite this paper

@inproceedings{Hamming2010InhibitionO, title={Inhibition of β-Cell Sodium-Calcium Exchange Enhances Glucose-Dependent Elevations in Cytoplasmic Calcium and Insulin Secretion}, author={Kevin S.C. Hamming and Daniel Soliman and Nicola J. Webster and Gavin J. Searle and Laura C. Matemisz and David A. Liknes and Xiao-Qing Dai and Thomas Pulinilkunnil and Michael J. Riedel and Jason R. B. Dyck and Patrick E Macdonald and Peter E. Light}, booktitle={Diabetes}, year={2010} }