Inhibition of α-class cytosolic human carbonic anhydrases I, II, IX and XII, and β-class fungal enzymes by carboxylic acids and their derivatives: new isoform-I selective nanomolar inhibitors.

@article{Sechi2012InhibitionO,
  title={Inhibition of α-class cytosolic human carbonic anhydrases I, II, IX and XII, and β-class fungal enzymes by carboxylic acids and their derivatives: new isoform-I selective nanomolar inhibitors.},
  author={Mario Sechi and Alessio Innocenti and Nicolino Pala and Dominga Rogolino and Mauro Carcelli and Andrea Scozzafava and Claudiu T. Supuran},
  journal={Bioorganic & medicinal chemistry letters},
  year={2012},
  volume={22 18},
  pages={
          5801-6
        }
}
The members of a focused series of carboxylic acids and of their derivatives (esters, amides and metal complexes) have been investigated as inhibitors of the main cytosolic/transmembrane carbonic anhydrase isoforms, CA I, II, IX and XII, belonging to the mammalian α-class of CAs. These enzymes are present in red blood cells in submillimolar concentration, and typical sulfonamide CA inhibitors do not selectively inhibit any of them. Among such isozymes, the isoform-I is an 'orphan' target that… CONTINUE READING