Inhibition mechanism of compound ethanol extracts from wuweizi (fructus schisandrae chinensis) on renal interstitial fibrosis in diabetic nephropathy model mice.

  title={Inhibition mechanism of compound ethanol extracts from wuweizi (fructus schisandrae chinensis) on renal interstitial fibrosis in diabetic nephropathy model mice.},
  author={Yanqiu Zhang and Daning Zhang and Mianzhi Zhang},
  journal={Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan},
  volume={32 4},

Herbal compound of pueraria and hawthorn alleviates fibrotic renal injury in diabetic fatty rats

RH alleviated 24 h urinary protein excretion, blood glucose level and renal injury in diabetic rats, reduced the expression of α-SMA and collagen IV, and increased expressions of PTEN and FN.

Huangqi (astragalus) decoction ameliorates diabetic nephropathy via IRS1-PI3K-GLUT signaling pathway.

It is suggested that HD prevents the development of diabetes and improves renal function in the db/db mice and HD regulation of the IRS1-PI3K-GLUT signaling pathway significantly improves diabetic nephropathy.

Schisantherin A ameliorates liver fibrosis through TGF-β1mediated activation of TAK1/MAPK and NF-κB pathways in vitro and in vivo.

HuangQi Decoction Improves Renal Tubulointerstitial Fibrosis in Mice by Inhibiting the Up-Regulation of Wnt/β-Catenin Signaling Pathway

HuangQi decoction could effectively inhibit the up-regulation of Wnt/β-catenin signaling pathway induced by UUO, implying a possible role in improving renal interstitial fibrosis.

Review of the therapeutic effects of the traditional Chinese medicine yuye decoction on diabetes mellitus and its complications

YYD exerted a therapeutic effect on diabetes and a preventive effect on diabetic complications and was placed on Astragalus membranaceus Bge.

Schisandra Inhibit Bleomycin-Induced Idiopathic Pulmonary Fibrosis in Rats via Suppressing M2 Macrophage Polarization

Idiopathic pulmonary fibrosis (IPF) is defined as a specific form of chronic, progressive fibrosing interstitial pneumonia of unknown cause and limited to the lungs. Schisandrae chinensis fructus

Effects of Schisandra chinensis Extract on the Learning and Memory Ability of Mice With Learning and Memory Disorders

SCE can significantly improve theLearning and memory ability of mice with learning and memory disorders, which may be related to its antioxidant effect.

Diabetic Complications: A Natural Product Perspective

With India becoming the capital of diabetes and its associated complications, the present natural products perspective is more evident and highlights the current natural products based research that has been done for the last five years in tackling diabetic complications.

A Network Pharmacology-Based Study on the Hepatoprotective Effect of Fructus Schisandrae

Molecular docking and network analysis were carried out to explore the hepatoprotective mechanism of Wuweizi as an effective therapeutic approach to treat liver disease.



Adiponectin reduces proteinuria in streptozotocin-induced diabetic Wistar rats

It is shown that chronic hyperadiponectinemia significantly alleviated the progression of proteinuria in early stage diabetic nephropathy.

Macrophages in streptozotocin-induced diabetic nephropathy: potential role in renal fibrosis.

Elements of the diabetic milieu can stimulate macrophages to promote fibroblast proliferation via IL-1- and PDGF-dependent pathways which may enhance renal fibrosis.

Association of monocyte chemoattractant protein-1 with renal tubular damage in diabetic nephropathy.

The relationship between inflammation, endothelial dysfunction and proteinuria in patients with diabetic nephropathy

Investigation of the possible relationship between inflammation, endothelial dysfunction and proteinuria in patients with diabetic nephropathy showed no correlations among pro-inflammatory cytokines concentrations and markers of vascular endotelial disfunction, but found TNF-α, IL-6, hsCRP and urinary protein concentrations are higher in the DN patients.

jun-N-terminal kinase regulates thrombin-induced PAI-1 gene expression in proximal tubular epithelial cells.

It is suggested that thrombin activates the JNK-AP-1 axis in a PKC- and src-dependent manner in PTEC and may represent a therapeutic target in acute and chronic tubulointerstitial damage.

Down-regulation of E-cadherin in mouse skin carcinoma cells enhances a migratory and invasive phenotype linked to matrix metalloproteinase-9 gelatinase expression.

The results indicate that in this cell system, the E-CD-mediated cell-cell contacts are involved in the down-regulation of MMP-9 expression, which triggers a migratory and invasive phenotype in mouse squamous carcinoma cells.

Fibroblasts in kidney fibrosis emerge via endothelial-to-mesenchymal transition.

It is demonstrated that endothelial cells also contribute to the emergence of fibroblasts during kidney fibrosis via the process of endothelial-to-mesenchymal transition (EndMT), and it is suggested that targeting EndMT might have therapeutic potential.

Impaired fibrinolytic activity in type II diabetes: correlation with urinary albumin excretion and progression of renal disease.

A prospective, randomized clinical trial in type II diabetes with PAI-1 inhibitors is needed to examine the effect of impaired fibrinolysis, as assessed by the ratio of plasminogen activator inhibitor (PAI- 1) to tissue-type plasmine activator (t-PA).

Transforming growth factor-beta-induced alpha-smooth muscle cell actin expression in renal proximal tubular cells is regulated by p38beta mitogen-activated protein kinase, extracellular signal-regulated protein kinase1,2 and the Smad signalling during epithelial-myofibroblast transdifferentiation.

  • A. SebeS. Leivonen I. Mucsi
  • Biology, Medicine
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
  • 2008
TGFbeta-induced alphaSMA expression is regulated by the coordinated activation of a complex system of parallel MAPK and Smad signalling pathways in renal proximal tubular cells during epithelial-mesenchymal transdifferentiation.