Inhibition kinetics and emodin cocrystal structure of a type II polyketide ketoreductase.


Type II polyketides are a class of natural products that include pharmaceutically important aromatic compounds such as the antibiotic tetracycline and antitumor compound doxorubicin. The type II polyketide synthase (PKS) is a complex consisting of 5-10 standalone domains homologous to fatty acid synthase (FAS). Polyketide ketoreductase (KR) provides regio… (More)
DOI: 10.1021/bi7016427


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