Inhibition by zinc of rhinovirus protein cleavage: interaction of zinc with capsid polypeptides.

@article{Korant1976InhibitionBZ,
  title={Inhibition by zinc of rhinovirus protein cleavage: interaction of zinc with capsid polypeptides.},
  author={Bruce Korant and Byron E. Butterworth},
  journal={Journal of virology},
  year={1976},
  volume={18 1},
  pages={298-306}
}
Zinic ions rapidly inhibit virus production in HeLa cells infected with human rhinovirus type 1A and lead to the accumulation of human rhinovirus type 1A precursor polypeptides. The degree to which cleavage of these precursors is inhibited is directly dependent on the quantity of cell-associated zinc. Proteolysis resumes after the removal of zinc-containing medium, and the accumulated viral precursors are cleaved predominantly to stable virus polypeptides. The precursors stabilized at the… CONTINUE READING
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