Inhibition by tamoxifen of estrogen-stimulated accumulation of preprolactin messenger ribonucleic acid.

@article{Spona1981InhibitionBT,
  title={Inhibition by tamoxifen of estrogen-stimulated accumulation of preprolactin messenger ribonucleic acid.},
  author={Juergen Vitalogic Spona and Heinz Leibl},
  journal={Biochimica et biophysica acta},
  year={1981},
  volume={656 1},
  pages={
          45-54
        }
}
Estrogens are involved in the stimulation of prolactin synthesis in the rat anterior pituitary. After 5 days of treatment with 17beta-estradiol, strong enhancement of [3H]leucine incorporation into prolactin an stimulation of translatable preprolactin mRNA, respectively, were noted. Increase in prolactin synthesis was found following daily application with estriol and the synthetic estrogen 1,3-dibenzoyloxy-17 beta-methyl-1,3,5(10)-estratrien-17 beta-ol (DB-EE2). The antiestrogen tamoxifen… CONTINUE READING
BETA