Inhibition by recombinant hirudins of experimental venous thrombosis and disseminated intravascular coagulation induced by tissue factor in rats.

@article{Freund1990InhibitionBR,
  title={Inhibition by recombinant hirudins of experimental venous thrombosis and disseminated intravascular coagulation induced by tissue factor in rats.},
  author={Monique Freund and J‐P. Cazenave and Michael Courtney and Eric Degryse and Carolyn A. Roitsch and Andr{\'e} Bernat and Denis Delebassee and Ghislain Defreyn and Jean Pierre Maffrand},
  journal={Thrombosis and haemostasis},
  year={1990},
  volume={63 2},
  pages={
          187-92
        }
}
Antithrombotic potency of recombinant hirudins rHV2, rHV2-Lys47 and rHV2-Arg47 was studied in a model of experimental thrombosis induced by tissue factor in the rat. Venous thrombosis was induced by i.v. injection of 25 mg/kg tissue factor followed by stasis of the inferior vena cava. In this model natural recombinant hirudins, rHV2 and rHV2-Lys47 injected 5 min before thrombo-plastin totally inhibited thrombosis in the same micrograms range as heparin or natural hirudin extracted from leeches… Expand
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