Inhibition by nitric oxide of the uptake of [3H]serotonin into rat brain synaptosomes.

  title={Inhibition by nitric oxide of the uptake of [3H]serotonin into rat brain synaptosomes.},
  author={Shinji Asano and Toshio T. Matsuda and Yoko Nakasu and Shuichiro Maeda and H. Nogi and A. Ramesha Baba},
  journal={Japanese journal of pharmacology},
  volume={75 2},
[3H]Serotonin (5-HT) uptake by synaptosomes of rat brain was dose-dependently inhibited by nitric oxide (NO) donors such as sodium nitroprusside (SNP), 3-(2-hydroxy-1-methyl-2-nitrosohydrazino)-N-methyl-1-propanamin e, 3-morpholinosydnonimine and S-nitroso-L-cysteine (NO-CYS). The inhibitory effect was blocked by reduced hemoglobin. The effect was not mimicked by ferrocyanide and ferricyanide. 8-Bromoguanosine 3',5'-cyclic monophosphate (8-bromo cGMP) did not affect [3H]5-HT uptake into rat… CONTINUE READING


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