Corpus ID: 24223896

Inhibition by nilutamide of the mitochondrial respiratory chain and ATP formation. Possible contribution to the adverse effects of this antiandrogen.

@article{Berson1994InhibitionBN,
  title={Inhibition by nilutamide of the mitochondrial respiratory chain and ATP formation. Possible contribution to the adverse effects of this antiandrogen.},
  author={Alain Berson and L. Schmets and C{\'e}cile Fisch and D. Fau and Claude Wolf and Bernard Fromenty and D Deschamps and Dominique Pessayre},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1994},
  volume={270 1},
  pages={
          167-76
        }
}
The effects of nilutamide on the mitochondrial respiratory chain were investigated in rats. In isolated mitochondria, nilutamide (100 microM) inhibited respiration that was supported by substrates feeding electrons into complex I of the respiratory chain but did not inhibit respiration that was supported by substrates donating electrons to complexes II, III or IV. Inhibition of complex I occurred without any lag time. In submitochondrial particles, nilutamide (100 microM) decreased both oxygen… Expand
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