Inhibition by glucose or leptin of hypothalamic neurons expressing neuropeptide Y requires changes in AMP-activated protein kinase activity

@article{Mountjoy2006InhibitionBG,
  title={Inhibition by glucose or leptin of hypothalamic neurons expressing neuropeptide Y requires changes in AMP-activated protein kinase activity},
  author={Philip D Mountjoy and Sarah J Bailey and Guy A Rutter},
  journal={Diabetologia},
  year={2006},
  volume={50},
  pages={168-177}
}
Changes in the activity of glucose-excited and glucose-inhibited neurons within the basomedial hypothalamus are key to the central regulation of satiety. However, the molecular mechanisms through which these cells respond to extracellular stimuli remain poorly understood. Here, we investigate the role of 5′-AMP-activated protein kinase (AMPK), a trimeric complex encoded by seven distinct genes of the PRKA family, in the responses to glucose and leptin of each cell type. The activity of isolated… CONTINUE READING

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