Inhibition by ginkgolides and bilobalide of the production of nitric oxide in macrophages (THP-1) but not in endothelial cells (HUVEC).

@article{Cheung2001InhibitionBG,
  title={Inhibition by ginkgolides and bilobalide of the production of nitric oxide in macrophages (THP-1) but not in endothelial cells (HUVEC).},
  author={Filly Cheung and Yaw L Siow and K O},
  journal={Biochemical pharmacology},
  year={2001},
  volume={61 4},
  pages={
          503-10
        }
}
Homocysteine stimulates inducible nitric oxide synthase expression in macrophages: Antagonizing effect of ginkgolides and bilobalide
TLDR
It is demonstrated that homocysteine, at pathophysiological concentrations, stimulates iNOS-mediated NO production in macrophages and EGb and its terpenoids can antagonize such stimulatory effect via antioxidation and attenuation of NF-κB activation.
Ganoderma lucidum inhibits inducible nitric oxide synthase expression in macrophages
  • C. WooR. Man K. O
  • Biology, Medicine
    Molecular and Cellular Biochemistry
  • 2005
TLDR
Results suggest that G. lucidum may exert a therapeutic effect against atherosclerosis via ameliorating iNOS-mediated NO overproduction in macrophages.
Hyperhomocysteinemia activates NF-kappaB and inducible nitric oxide synthase in the kidney.
TLDR
Hyperhomocysteemia alone can activate NF-kappaB and hence induce iNOS-mediated nitric oxide production in the kidney leading to increased peroxynitrite formation, which may represent one of the mechanisms for renal dysfunction in hyperhomocysteinemia.
An investigation into pro-apoptotic targets in experimental glaucoma and the neuroprotective effects of Ginkgo biloba in retinal ganglion cells
TLDR
It is suggested that Ginkgolide B can be neuroprotective to RGCs in preventing apoptosis and cell death, therefore may be of use as a neuroProtective strategy in glaucoma management.
Bilobalide and neuroprotection.
Bilobalide, a unique constituent of Ginkgo biloba, inhibits inflammatory pain in rats
TLDR
Data show that bilobalide is a potent anti-inflammatory and antihyperalgesic agent, the therapeutic effects of which are mediated in part through a central site of action, and may account for the therapeutic action of the whole extract G. biloba.
Neuroprotective effects of Ginkgo biloba extract
TLDR
The experimental results on the mechanism of neuroprotection induced by standardized extract of Ginkgo biloba leaves (EGb 761) and its constituents include those on cerebral blood flow, neurotransmitter systems, cellular redox state and nitric oxide level.
Hepatic fibrosis in biliary-obstructed rats is prevented by Ginkgo biloba treatment.
TLDR
The results suggest that Ginkgo biloba protects the liver from oxidative damage following BDL in rats, and possibly involves the inhibition of neutrophil infiltration and lipid peroxidation; thus, restoration of oxidant and antioxidant status in the tissue.
Influence of lipophilicity and stereochemistry at the C7 position on the cardioprotective and antioxidant effect of ginkgolides during rat heart ischemia and reperfusion
TLDR
It was concluded that a high lipophilicity is not an absolute prerequisite for a strong anti‐PAF effect for ginkgolides, whereas it appears essential for cardioprotection.
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