Inhibition by ginkgolides and bilobalide of the production of nitric oxide in macrophages (THP-1) but not in endothelial cells (HUVEC).

@article{Cheung2001InhibitionBG,
  title={Inhibition by ginkgolides and bilobalide of the production of nitric oxide in macrophages (THP-1) but not in endothelial cells (HUVEC).},
  author={F. Cheung and Y. Siow and O K.},
  journal={Biochemical pharmacology},
  year={2001},
  volume={61 4},
  pages={
          503-10
        }
}
  • F. Cheung, Y. Siow, K. O
  • Published 2001
  • Chemistry, Medicine
  • Biochemical pharmacology
  • Nitric oxide (NO) is a principal mediator in many physiological and pathological processes. NO produced by constitutive nitric oxide synthase in endothelial cells (eNOS) acts as a vasodilator, whereas excess NO production due to elevated expression of inducible nitric oxide synthase (iNOS) may produce cytotoxic effects to cells in the vascular wall. We demonstrated in our previous work that the extract of Ginkgo biloba leaves (EGb) inhibits iNOS-mediated NO production. The objective of the… CONTINUE READING
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