Inhibition by female sex hormones of collagen gel contraction mediated by retinal pigment epithelial cells.

@article{Kimura2014InhibitionBF,
  title={Inhibition by female sex hormones of collagen gel contraction mediated by retinal pigment epithelial cells.},
  author={Kazuhiro Kimura and Tomoko Orita and Youichiro Fujitsu and Yang Liu and Makiko Wakuta and Noritugu Morishige and Katsuyoshi Suzuki and Koh-hei Sonoda},
  journal={Investigative ophthalmology & visual science},
  year={2014},
  volume={55 4},
  pages={
          2621-30
        }
}
PURPOSE Collagen contraction mediated by retinal pigment epithelial (RPE) cells contributes to the pathogenesis of proliferative vitreoretinopathy (PVR). We examined the effects of sex hormones on this process. METHODS Mouse RPE cells were cultured in a type I collagen gel and exposed to 17β-estradiol, progesterone, or dehydro-epiandrosterone. Collagen contraction induced by transforming growth factor-β2 (TGF-β2) was determined by measurement of gel diameter. Expression of α-smooth muscle… CONTINUE READING
BETA

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 10 CITATIONS

Attenuation of EMT in RPE cells and subretinal fibrosis by an RAR-γ agonist

  • Journal of Molecular Medicine
  • 2015
VIEW 5 EXCERPTS
CITES METHODS & BACKGROUND
HIGHLY INFLUENCED

Protective Effects of Fucoidan on Epithelial-Mesenchymal Transition of Retinal Pigment Epithelial Cells and Progression of Proliferative Vitreoretinopathy.

  • Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
  • 2018