Inhibition by colchicine of human lymphocytotoxic function: dependence on cell-bound drug level, spontaneous reversibility and antagonism by desacetylcolchicine (DAC).

Abstract

Colchicine elicits inhibition of spontaneous, PHA-dependent and antibody-dependent forms of lymphocytotoxicity of peripheral blood lymphocytes (PBL) against allogeneic target cells. The findings are that it does so in cell-bound form and to near-maximum effect in the amount of this produced in PBL exposed to it at 10(-6)M concentration for 2 h at 37 degrees… (More)

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@article{Thomson1983InhibitionBC, title={Inhibition by colchicine of human lymphocytotoxic function: dependence on cell-bound drug level, spontaneous reversibility and antagonism by desacetylcolchicine (DAC).}, author={A E Thomson and B K Dabrowska-Bernstein}, journal={Leukemia research}, year={1983}, volume={7 2}, pages={175-92} }