Inhibition by carbapenem antibiotic imipenem of intestinal absorption of valproic acid in rats.

@article{Torii2001InhibitionBC,
  title={Inhibition by carbapenem antibiotic imipenem of intestinal absorption of valproic acid in rats.},
  author={Mayumi Torii and Yoshiharu Takiguchi and Fumitoshi Saito and Miyako Izumi and Mltsuhlro Yokota},
  journal={The Journal of pharmacy and pharmacology},
  year={2001},
  volume={53 6},
  pages={
          823-9
        }
}
The concomitant use of carbapenem antibiotics with valproic acid has been prohibited because panipenem induced a decrease in plasma concentration of valproic acid in epileptic patients during valproic acid therapy. To clarify the possible mechanism of the carbapenem-valproic acid interaction, we investigated the effect of imipenem on the pharmacokinetic behaviour of valproic acid in rats. Co-administration of imipenem (30 mg kg(-1), i.v.) induced a decrease in the peak plasma concentration of… CONTINUE READING
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